Copyright © 2008 The Institute of Electronics, Information and Communication Engineers
Regular Section -- Papers -- Biological Engineering |
Noninvasive Femur Bone Volume Estimation Based on X-Ray Attenuation of a Single Radiographic Image and Medical Knowledge*
1 The authors are with the Department of Electronics and Telecommunication Engineering, King Mongkut's University of Technology Thonburi, Pracha-uthit Road, Bangkok 10140, Thailand. E-mail: supaporn_kai{at}utcc.ac.th
Bone Mineral Density (BMD) is an indicator of osteoporosis that is an increasingly serious disease, particularly for the elderly. To calculate BMD, we need to measure the volume of the femur in a noninvasive way. In this paper, we propose a noninvasive bone volume measurement method using x-ray attenuation on radiography and medical knowledge. The absolute thickness at one reference pixel and the relative thickness at all pixels of the bone in the x-ray image are used to calculate the volume and the BMD. First, the absolute bone thickness of one particular pixel is estimated by the known geometric shape of a specific bone part as medical knowledge. The relative bone thicknesses of all pixels are then calculated by x-ray attenuation of each pixel. Finally, given the absolute bone thickness of the reference pixel, the absolute bone thickness of all pixels is mapped. To evaluate the performance of the proposed method, experiments on 300 subjects were performed. We found that the method provides good estimations of real BMD values of femur bone. Estimates shows a high linear correlation of 0.96 between the volume Bone Mineral Density (vBMD) of CT-SCAN and computed vBMD (all P > 0.001). The BMD results reveal 3.23% difference in volume from the BMD of CT-SCAN.
Key Words: medical image processing, osteoporosis, bone mineral density, active contour model, volume BMD, linear attenuation coefficients
Manuscript received May 15, 2007. Manuscript revised October 18, 2007.
* This work was supported in part by a grant from the Ministry University Affair, Thailand.
Reference
[1] J.A. Kanis, P.D. Delmas, P. Burckhardt, C. Cooper, and D.J. Torgerson, "Guidelines for diagnosis and management of osteoporosis," The European Foundation for Osteoporosis and Bone Disease. Osteoporos Int, vol.7, pp.590–406, 1997. [2] "IOF: Facts and statistics about osteoporosis and its impact. International Osteoporosis," www.iofbonehealth.org/facts-and-statistics.html Foundation 2007. [3] T. Beck, C. Ruff, K. Warden, W. Scott, and G. Rao, "Predicting femoral neck strength from bone mineral data," A structural approach.Invest Radiol, vol.25, pp.6–18, 1990. [4] A. Pietrobelli, C. Formica, Z. Wang, and S. Heymsfield, "Dual-energy X-ray absorptiometry body composition model: Review of physical concepts," Am Physiological Soc, pp.941–951, 1996. [5] J. Center, T. Nguyen, N. Pocock, and J. Eisman, "Volumetric bone density at the femoral neck as a common measure of hip fracture risk for men and women," Endocrine Soc, vol.6, pp.2776–2782, 2004. [6] D. Hemmy, D. David, and G. Herman, "Three-dimensional reconstruction of craniofacial deformation using computed tomographic," Neurosurgery, vol.13, pp.534–541, 1983. [7] D. Carter, M. Bouxsein, and R. Marcus, "New approaches for interpreting projected bone densitometry data," J Bone Miner Res, vol.7, pp.37–45, 1992. [8] A. Louis and P. Maass, "Contour reconstruction in 3-D X-ray CT," IEEE Trans. Med. Imaging, vol.12, no.4, pp.764–769, Dec. 1993. [9] Y. Seo, J. Kurhanewicz, B. Franc, R. Hawkins, and B. Hasegawa, "Improved prostate cancer imaging with SPECT/CT and MRI/MRSI," IEEE Trans. Nucl. Sci., vol.52, no.5, pp.1316–1320, Oct. 2005. [10] J. Novosad, F. Cheriet, Y. Petit, and H. Labelle, "Three-dimensional (3-D) reconstruction of the spine from a single X-ray image and prior vertebra models," IEEE Trans. Biomed. Eng., vol.51, no.9, pp.1628–1639, Sept. 2004. [11] M. Kass, A. Witkin, and D. Terzopoulos, "Snakes: Active contour models," Int. J. Comput. Vis., vol.1, no.4, pp.321–331, Jan. 1988. [12] T. Cootes, A. Hill, C. Taylor, and J. Haslam, "The use of active shape models for locating structures in medical images," Image Vis. Comput., vol.12, no.6, pp.355–366, July 1994. [13] J. Sethian, Level Set Methods: Evolving Interfaces in Geometry, Fluid Mechanics, Computer Vision and Materials Sciences, Cambridge University Press, 1996. [14] L. Cohen and I. Cohen, "Finite-element methods for active contour models and balloons for 2-D and 3-D images," IEEE Trans. Pattern Anal. Mach. Intell., vol.15, no.11, pp.1131–1147, Nov. 1993. [15] D. Pham, C. Xu, and J. Prince, "Current methods in medical image segmentation," Annu. Rev. Biomed. Eng., vol.2, pp.315–337, Aug. 2000. [16] T. Ziylan and K. Murshid, "An analysis of anatolian human femur anthropometry," Turk J Med Sci, vol.32, pp.231–235, 2002. [17] J. Canny, "A computational approach to edge detection," IEEE Trans. Pattern Anal. Mach. Intell., vol.8, no.6, pp.679–698, 1986. [18] P. Van der Zwet, M. Nettesheim, J. Gerbrands, and J. Reiber, "Derivation of optimal filters for the detection of coronary arteries," IEEE Trans. Med. Imaging, vol.17, no.1, pp.108–120, Feb. 1998. [19] M. Kass, A. Witkin, and D. Terzopoulos, "Snakes: Active contour models," Int. J. Comput. Vis., vol.1, pp.321–331, 1988. [20] C. Chang, S. Hwang, and D. Buehrer, "A shape recognition scheme based on relative distances of feature points from the centroid," Elsevier Pattern Recog., vol.24, no.11, pp.1053–1063, 1991. [21] T. Tang, R. Ellis, and G. Fichtinger, "Fiducial registration from a single X-ray image; A new technique for fluoroscopic guidance and radiotherapy," Proc. MICCAI, vol.1935, pp.502–511, 2000. [22] G. Aboutanos, J. Nikanne, N. Watkins, and B. Dawan, "Model creation and deformation for the automatic segmentation of the brain in MR images," IEEE Trans. Biomed. Eng., vol.46, no.11, pp.1346–1356, Nov. 1999. [23] Z. Yaniv, Fluoroscopic X-ray image processing and registration for computer-aided orthopedic surgery, Masters Thesis, The Hebrew University of Jerusalem, 1998. [24] S. Orlov, "Theory of three dimensional reconstruction. 1.Conditions of a complete set of projections," Sou. Phys.-Crystallogr, vol.20, no.1, pp.312–314, 1976.
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